Synthetic Control of Tertiary Helical Structures in Short Peptides
نویسندگان
چکیده
منابع مشابه
Effective stabilisation of alpha-helical structures in short peptides with acetylenic cross-linking agents.
Supplementary Information General Materials. The starting materials were all commercially available, and 1,4-bis(2hydroxyethoxy)-2-butyne (5b) and 2,4-hexadiyne-1,6-diol (8) were prepared according to the literature procedures. The cross-linking agents 3a, 3b, and 4b were reported previously, however, the physical and spectroscopic data of 4b were not described in the literature and were presen...
متن کاملDifferent membrane anchoring positions of tryptophan and lysine in synthetic transmembrane alpha-helical peptides.
Specific interactions of membrane proteins with the membrane interfacial region potentially define protein position with respect to the lipid environment. We investigated the proposed roles of tryptophan and lysine side chains as "anchoring" residues of transmembrane proteins. Model systems were employed, consisting of phosphatidylcholine lipids and hydrophobic alpha-helical peptides, flanked e...
متن کاملClassification of Helical Structures
The classification of helical structures is of fundamental importance in several domains including natural sciences, engineering and medicine. Helixes are complicated structures to separate due to their highly non-linear temporal nature. Several studies have examined the famous two-spiral problem using several types of neural architectures. It has been observed that neural networks can be relia...
متن کاملPersistent Currents in Helical Structures
Recent discovery of mesoscopic electronic structures, in particular the carbon nanotubes, made necessary an investigation of what effect may helical symmetry of the conductor (metal or semiconductor) have on the persistent current oscillations. We investigate persistent currents in helical structures which are non-decaying in time, not requiring a voltage bias, dissipationless stationary flow o...
متن کاملHelical Surface Structures
Over the past few years there has been growing interest in helical magnetic field structures seen at the solar surface, in coronal mass ejections, as well as in the solar wind. Although there is a great deal of randomness in the data, on average the extended structures are mostly left-handed on the northern hemisphere and right-handed on the southern. Surface field structures are also classifie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2018
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.8b10082